FAQ:

When trying to open thunderbird, I get the error message "Thunderbird is already running, but is not responding", but I am not currently running Thunderbird.

Answer:

The solution is http://kb.mozillazine.org/Profile_in_use?.

To automatically clean locks in your Firefox profile run the following script (~bollig/cleanThunderbird.sh):

#!/bin/bash

# Use this script to clean locks inside the .thunderbird directory that
# prevent Thunderbird from running on multiple machines that share an
# NFS system. If you open Thunderbird and get a window claiming,
# "another instance of this application is already running [...]"
# running this script will enable you to open the application on another
# host.

files=`find ~/.thunderbird -name "*lock"`
for file in `echo $files`
do
        echo "removing $file..."
        rm "$file"
done

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-- StevenHenke - 02 Mar 2008